一、課程簡介:
課程主要目的、在於探討細胞在受到來自外界或細胞內刺激因子的作用後，細胞訊息傳遞變化所導致細胞的生長與死亡分子機制為何？並深入探討當前細胞生長調控的一些重要課題。因此、課程內容將自細胞訊息傳遞機轉開始，討論細胞分裂如何被調控，進而探討細胞的生長、分化及死亡調控機制。


日期 主題
93-9-14 Overview
93-9-21 Basic concepts on cell cycle and signaling cascade
93-10-5 Mitogen and Receptors: Ras signaling
*93-10-12 Intracellular signals (I): MAPK cascades
93-10-19 Intracellular signals (II): PLC, PI3K and TGF- signaling
93-10-26 Intracellular Signals (III) :cytokine Signaling
*93-11-02 The Cell Cycle Engine
93-11-09 Cellular Signaling and Cell Progression Cycle
93-11-16 期中考
93-11-23 Apoptotic (I): death machinery
93-11-30 Apoptotic (II): the mitochondria
*93-12-7 Integrin Signaling (I): Growth, Differentiation and Death
93-12-14 Integrin Signaling (II): Growth, Differentiation and Death
93-12-21 Signaling specificity and cross talk
*93-12-28 Cellular Stress in Cell Growth and Death
94-1-04 Cancer development
94-1-11 期末考


二、成績考核
課堂小考：10分 期中考試：50分 期末考試：50分


三、參考書目:
1. Signal Transduction, Edited by C-H Heldin and M Purton, 1996 Chapman & Hall.
2. The Cell Cycle: an introduction, Edited by A Murray and T Hunt, 1996 Freeman.
3. Principles of Cell Proliferation. Edited by John K. 2001 Health Blackwell Sciences